Retatrutide is a triple agonist of GLP-1, GIP, and glucagon. This combination works in an integrated manner to reduce appetite and increase satiety, improve glycaemic homeostasis, and promote greater energy expenditure/thermogenesis via activity at the glucagon receptor.
Key Benefits
Marked reduction in body weight in clinical studies, with high-impact results in obesity.
Improved glycaemic control and cardiometabolic markers (e.g., inflammatory lipids and blood pressure reported in readouts).
Reduced liver fat and improvements associated with metabolic liver disease (MASLD/MASH) in a Phase 2a study.
Quality of weight loss (body composition): evidence suggests a greater reduction in fat mass, without a disproportionate increase in lean mass loss, in body-composition sub-studies.
Tirzepatide is a dual agonist of GIP and GLP-1 receptors, acting in an integrated way across incretin pathways. It increases insulin secretion in a glucose-dependent manner and improves glycaemic regulation (reducing peaks and variability). It also acts on appetite/satiety centres, contributing to reduced food intake.
Key Benefits
Significant reduction in body weight in studies involving people with obesity/overweight (results depend on dose, duration, and adherence).
Robust improvement in glycaemic control (HbA1c) in people with type 2 diabetes, with dose-dependent reductions observed in clinical trials.
Cardiometabolic improvements associated with weight loss and incretin pathway activity.
Maintenance of weight loss with continued treatment, demonstrating sustained outcomes when use is maintained within protocol (in maintenance trials).
A peptide that acts like a “site foreman”. It organises the repair process, improves cellular communication (cell signalling), and helps ensure the “materials” (collagen) are laid down correctly. It is particularly supportive for the structural integrity of tendons and ligaments.
BPC-157 is often referred to as “the healing peptide” due to its ability to accelerate processes the body would otherwise take months to complete naturally.
Key Benefits
Accelerated regeneration: supports recovery of tendons, ligaments, and muscle tissue, promoting more functional healing and potentially reducing the risk of fibrosis.
Anti-inflammatory action: helps modulate inflammation, with potential systemic effects in acute and chronic processes.
Gut health (cytoprotection): supports protection and regeneration of the gastric and intestinal mucosa; literature has investigated ulcers and intestinal inflammation.
Angiogenesis: may stimulate new blood vessel formation, improving circulation, nutrient delivery, and tissue recovery.
A synergistic combination developed to stimulate the body’s natural release of growth hormone (GH) in a physiology-aligned way. By acting through two complementary pathways, it supports more consistent GH pulses and IGF-1 support, helping to sustain performance, recovery, and body composition.
Key Benefits
Stimulates the body’s own GH: helps the body release growth hormone in a pattern closer to natural physiology (in “pulses”).
Supports recovery and repair: may aid recovery (sleep, post-training, regeneration) by reinforcing GH/IGF-1–related signalling.
Body composition support: associated with a better balance between lean mass and fat, supporting body recomposition.
More efficient metabolism: may promote energy utilisation and support fat and protein metabolism.
Vitality and performance: many people seek a greater sense of energy and a steadier performance rhythm throughout the protocol.
A synthetic peptide composed of four amino acids (Ala–Glu–Asp–Gly).
It “resets” the cellular biological clock and synchronises the pineal gland to restore the circadian cycle and the rhythmic secretion of melatonin.
It is used in protocols focused on systemic rejuvenation, the management of sleep disorders and jet lag, immune system support in older adults, and the prevention of cognitive decline.
Key Benefits
Telomere extension: by activating telomerase, it may allow cells to divide for longer, helping to counter cellular senescence.
Circadian rhythm regulation: supports natural melatonin production by the pineal gland, resulting in better sleep quality.
Antioxidant action: reduces lipid oxidation and helps counter free radicals.
Metabolic health: studies suggest improvements in insulin sensitivity and lipid profile.
Prevention of age-related diseases: potential to reduce the incidence of tumours and neurodegenerative diseases.