MOTS-c is a peptide produced by the mitochondrion (the cell’s “energy plant”). It is being studied for helping the body use energy more efficiently, by stimulating a pathway similar to the one activated by exercise and by metformin. As a result, it may support the use of fat for energy and improve the way muscles take up sugar (glucose).
Key Benefits
Insulin sensitivity: significantly improves how the body processes sugar, helping to counter insulin resistance.
Weight management: supports fat oxidation and may help prevent weight gain caused by high-fat diets.
Physical performance: increases endurance capacity and mitochondrial biogenesis (the creation of new cellular “power plants”).
Longevity and anti-ageing: its replenishment is associated with protection against degenerative diseases.
Bone health: studies suggest it may help prevent osteoporosis by promoting osteoblast differentiation.
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The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Prevents Diet-Induced Obesity and Insulin Resistance — Lee, C., et al. (2015), Cell Metabolism. This is the landmark study that identified the peptide.
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