Retatrutide (40mg)
Mechanism of Action
Retatrutide is a triple agonist of GLP-1, GIP, and glucagon receptors. This combination works in an integrated manner to reduce appetite and increase satiety, improve glycaemic homeostasis, and promote greater energy expenditure/thermogenesis via activity at the glucagon receptor.
Key Benefits
- Marked reduction in body weight in clinical studies, with high-impact results in obesity.
- Improved glycaemic control and cardiometabolic markers (e.g., inflammatory lipids and blood pressure reported in readouts).
- Reduction in liver fat and improvements associated with metabolic liver disease (MASLD/MASH) in a Phase 2a study.
- Quality of weight loss (body composition): evidence suggests a greater reduction in fat mass, without a disproportionate increase in lean mass loss, in body-composition sub-studies.
- Tolerability profile consistent with the incretin class, with gastrointestinal events most commonly reported in studies (e.g., nausea, diarrhoea, and constipation).
Mechanism of Action
Retatrutide is a triple agonist of GLP-1, GIP, and glucagon receptors. This combination works in an integrated manner to reduce appetite and increase satiety, improve glycaemic homeostasis, and promote greater energy expenditure/thermogenesis via activity at the glucagon receptor.
Key Benefits
– Marked reduction in body weight in clinical studies, with high-impact results in obesity.
– Improved glycaemic control and cardiometabolic markers (e.g., inflammatory lipids and blood pressure reported in readouts).
– Reduction in liver fat and improvements associated with metabolic liver disease (MASLD/MASH) in a Phase 2a study.
– Quality of weight loss (body composition): evidence suggests a greater reduction in fat mass, without a disproportionate increase in lean mass loss, in body-composition sub-studies.
– Tolerability profile consistent with the incretin class, with gastrointestinal events most commonly reported in studies (e.g., nausea, diarrhoea, and constipation).
Technical Details
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Batteries Required?
DOSING USED IN PHASE 3 STUDIES
In the most recent studies from the TRIUMPH programme (Phase 3), retatrutide was administered as follows:
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Route: Subcutaneous
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Frequency: Once weekly
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Study duration: Approximately 68 weeks
Recommended Dosage (Clinical Research Escalation Model)
Retatrutide is administered once weekly using a gradual dose escalation to improve tolerability.
Dose Escalation Structure
Phase Weekly Dose
Weeks 1–4 1 mg
Weeks 5–8 2 mg
Weeks 9–12 4 mg
Maintenance (research range) 6–8 mg
Clinical trials have evaluated doses up to 12 mg once weekly with gradual titration.
